University of Geneva, Switzerland
Title: Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals
Biography: Panteleimon Giannakopoulos
We investigated whether subtle cognitive deterioration in healthy elderly individuals could be predicted by ASL imaging andrnEEG markers. A longitudinal study included 75 stable controls (sCON) and 73 deteriorated controls (d-CON) at 18-monthrnclinical follow-up and 65 patients with mild cognitive impairment (MCI). Continuous EEG was recorded during a n-back workingrnmemory task and two-dimensional pulsed ASL was performed at the baseline visit. Reduced ASL in the posterior cingulate cortexrnwas associated with the development of subtle neuropsychological deficits. Three EEG indices distinguished the two control groups:rnalpha and beta even related desynchronization (dCON > sCON) and beta inter-trial coherence (dCON < sCON). These results willrnbe discussed as a paradigm of predictive biomarkers in preclinical forms of dementia.
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