6^th International Conference on Vascular Dementia Feb 27-Mar 01, 2017 Amsterdam, Netherlands

Dr. Federoff will oversee and guide the development of UC Irvine Health. In addition to leading the School of Medicine, he will provide strategic direction for the clinical programs of UC Irvine Medical Center and all affiliated patient care centers and will ensure the alignment of the clinical enterprise and the physicians’ practice plan with the university’s academic and research missions. He will also provide guidance on the development and integration of UCI’s health-related academic programs in nursing science, public health and pharmaceutical sciences.

pharmaceutical sciences, nursing science

David has worked in community based mental health services in the UK for over thirty years developing services for people with complex care needs and enduring mental health problems in a career spanning the voluntary sector, local authority services, and the NHS.. From 2009 - 2011 he was the Dementia Implementation Lead for Commissioning Support for London, working with commissioners across London to improve dementia services. He is an independent writer and researcher on dementia support and services for Black and minority ethnic communities, working with a number of projects and initiatives.

Dementia, Mental Health

Perry received his bachelors of arts degree in zoology with high honors from University of California, Santa Barbara. After graduation, he headed to Scripps Institution of Oceanography and obtained his Ph.D. in marine biology under David Epel in 1979. He then received a postdoctoral fellowship in the Department of Cell Biology in the laboratories of Dr. Bill Brinkley and Joseph Bryan at Baylor College of Medicine where he laid the foundation for his observations of abnormalities in cell structures. In 1982, Perry joined the faculty of Case Western Reserve University, where he currently holds an adjunct appointment. He is distinguished as one of the top Alzheimer’s disease researchers with over 800 publications, one of the top 100 most-cited scientists in neuroscience and behavior and one of the top 25 scientists in free radical research. Perry has been cited over 23,000 times and is recognized as an ISI highly cited researcher. Perry is editor for numerous journals and is editor-in-chief for the Journal of Alzheimer's Disease. He is a fellow of the American Association for the Advancement of Sciences and past-president of the American Association of Neuropathologists, as well as a member of the Dana Alliance for Brain Initiatives. Perry is recognized internationally for his work. He is a Foreign Correspondent Member of the Spanish Royal Academy of Sciences and a Foreign Member of the Mexican National Academy of Sciences, and recent recipient of the National Plaque of Honor from the Republic of Panama Ministry of Science and Technology.

Brain disorders, Dementia, Neurology and Neurosugery

Professor and head of department in Grant Medical College & Sir JJ Group of hospitals 1991-2002. Professor Emeritus - Grant Medical College & Sir JJ Group of Hospital September 2005 till date. National coordinator for World Federation of Neurology Education Continuum-CME programme since 2005. Member of the WHO International Advisory Group for the Revision of ICD 10, Diseases of the Nervous System in the area of Infections of the Nervous System - January 2010 Member - World Federation of Neurology Education Committee since 2010 till date. Chair - World Federation of Neurology Teaching Course Committee 2014.

Neurology and Neurosugery

Born in Jammu-Tawi, India. After receiving Bachelor’s degree in Pharmaceutical Technology from the Birla Institute of Technology, Pilani, India, Rameshwar K. Sharma in 1960 entered the University of Connecticut for graduate work in Medicinal Chemistry and received his Ph.D. in 1963. Subsequently, after several Post-doctoral positions, including at the Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, he joined the University of Tennessee Medical Center at Memphis in 1970 where he rose to the rank of Full Tenured Professor of Biochemistry and Physiology. During this period through NIH Special Fellowship he spent two-years Sabbatical as a Visiting Professor at the McArdle Laboratory University of Wisconsin, Madison, in Dr. Henry Pitot’s lab, and subsequently additional two-years Sabbatical at the NIH, Bethesda in Dr. Michael Cashel’s lab. After Full Professorship at the Case Western University and Founder and Head of the Unit of Regulatory Biology at the Cleveland Clinic Foundation, Cleveland Ohio, he joined the University of Medicine and Dentistry at New Jersey as the Professor and Head of The Unit of Regulatory and Molecular Biology. Since July 2006 he is at the Salus University as a Distinguished Professor of Biochemistry and Molecular Biology. In a period spanning four decades, his research team has dedicated itself to the advancement of the field of membrane guanylate cyclase in the vertebrate systems. A few of its core findings that have impacted this and the field of cellular signal transduction follow. (1) With the discovery of the first membrane guanylate cyclase, ANF-RGC that was also the hormone receptor of ANF, the membrane guanylate cyclase surface receptor family was established. (2) It had a unique signal transduction mechanism. Instead of GTP in G-Protein signaling, it was regulated by ATP through its ARM module (ARM). The complete dissection of the module, followed through the concept-based analysis, localized a WTAPELL motif that controlled the entire signal transduction process, it was, then, predicted that this motif is the one that controls the ANF-RGC-dependent blood pressure in vasculature. This has now been proven true through the construction of the mouse genetic model. The mice lacking this motif are hypertensive. (3) The discovery and molecular characterization of the photoreceptor ROS-GC is a land mark event in the phototransduction field. It filled in the gap on the identity of the source of cyclic GMP that serves as a second messenger of the LIGHT signal; and made it possible to explain the principles of phototransduction in molecular and physiological terms. It also impacted the core membrane guanylate cyclase field by branching it into two: a transducer of both the hormone receptor and the intracellularly-generated Ca2+ signals. (4) ROS-GC field took additional direction when it was demonstrated that, besides phototransduction, it is biochemically linked with the transduction mechanisms of the inner segments of the retina, olfactory cilia and the olfactory bulb neurons. (5) The demonstration that ROS-GC is a Ca2+-bimodal switch, generated a new revolutionary concept where theoretically ROS-GC could be modulated through two different modes of Ca2+ signaling: via Ca2+-sensor GCAPS and S100B, the latter stimulating it and the mode found exclusively in cones and absent in rods. (6) Recently, an additional model of the photoreceptor ROS-GC1 has been disclosed. ROS-GC1 is responsive to the bicarbonate signal; it is not the pH effect, rather it binds to a specific motif of the ROS-GC and transduces the signal in generation of cyclic GMP. Preliminary findings suggest that this novel transduction system is present in a small number of mouse cones, and, importantly, is absent in the rods. This opens up a new area of sensory transduction mechanism, where it is meant to communicate with the external atmospheric carbon dioxide. The carbon dioxide is sensed through carbonic anhydrase, whose subtype has been detected in some cones, it converts CO2 to the bicarbonate, which, then, becomes the second messenger of CO2 and a signaling agent of ROS-GC1. Threaded through this past history and step-by-step gain in the field, This investigator feels fortunate that his group has made these important contributions in generating the field of membrane guanylate cyclase, establishing that cyclic GMP is an ubiquitous intracellular second messenger in prokaryotes and eukaryotes and that it plays a critical role in the control of physiological processes of cardiac vasculature, smooth muscle relaxation, blood volume, cellular growth, sensory transduction, neural plasticity, learning and memory. It is also gratifying to know that during this course he has been able to train and guide more than 35 doctoral and post-doctoral students, author 184 peer-reviewed research articles, including the editorship of three books, Special Editorship of two journals of Molecular and Cellular Biochemistry and the e-book editor of the Frontiers Molecular Neuroscience Research Topic, all focused on the field of membrane guanylate cyclases. At present I am on the editorial board of four international journals: Associate editor of the Frontiers in Molecular Neuroscience, Journal of Molecular and Cellular Biochemistry, Journal of Signal Transduction, Journal of Membrane Science & Technology. I am also the founding father and the President of the Guanylate Cyclase Innovative Biotechnology.

Neurology and Neuropharmacology

Claude M Wischik holds the Chair in Old Age Psychiatry at the University of Aberdeen in Scotland, and is Executive Chairman of TauRx Pharmaceuticals. He studied medicine in Australia, completed his PhD at the Laboratory of Molecular Biology in Cambridge, and also higher psychiatric training in Cambridge. He was the first to identify Tau protein as the main constituent of the Alzheimer tangle and developed the fi rst Tau Aggregation Inhibitors. He has published 121 papers and holds 11 patent groups based on his work with over 40 individual patents.

Alzheimer’s disease and Dementia

Professor of Neurosurgery in the Updating Course supported by the University of Bari and the Apulia Region “Patient Management: Interrelation between Medical Physicians and Healthcare givers,” University Hospital of Bari, Italy SURGICAL SKILLS AND EXPERIENCE Performed over 4,500 neurosurgical operations of the following types: -cranial traumas (950) -spinal cord traumas (500) -benign and malignant endocranial tumours (1100) -benign and malignant spinal cord tumours (400) -hemorrhagic vascular pathologies (400) -cerebral abcesses (60) -cerebral and spinal parasitosis (30) -pediatric neurosurgery (300) -functional neurosurgery (50) -cervical, dorsal, lumbar disk hernias and degenerative diseases (900) MAIN RESEARCH AND SCIENTIFIC SKILLS RESEARCH PROJECT FUNDS INTERNATIONAL JOURNAL REFEREE MAIN CONGRESS PARTICIPATION MAIN PUBLICATIONS MAIN PUBLICATION RECOGNITION AWARD

Cranio-spinal neurotraumatology with clinical and experimental research in traumatic patients. Spinal neurosurgery in degenerative diseases with decompression and stabilization as well as reconstructive techniques. Oncological neurosurgery (cerebral and medullary) with anatomo-pathological and genetic studies. Vascular neurosurgery in the treatment of vascular malformations and haemorrhages. Neurosurgery in cerebral and spinal parasitosis. Pediatric neurosurgery with studies in the treatment of childhood malformations, tumours and vascular pathologies of the brain and spine. Functional neurosurgery with the application of beta-ray sources and the Argon laser in stereotactic therapy of degenerative, vascular and tumour pathologies.

Graduated in Biological Sciences (D.Sc.) and in Medicine and Surgery (M.D.) - Associate Professor of Pharmacology at University of Pavia -Teaching Pharmacology for students in Biological Sciences and in Chemistry - Visiting: (1) Department of Neurology and (2) Cerebral Metabolism Research Laboratory, University of Lund, Sweden; (3) Department of Psychobiology, University of California ICI, U.S.A.; (4) Max Plank Institute for Neurochemistry, University of Gottingen, Germany; (5) San Diego Alzheimer’s Disease Research Center, University of California, San Diego, U.S.A.. Research activities: biochemical studies (Functional Proteomics and Metabolomics) on Physiopathology and Pharmacology of the Central Nervous System in experimental conditions of hypoxia, ischaemia, hyperammoniaemia, ipoglycaemia on the cerebral energy metabolism and actions of drugs on the brain energy state; molecular mechanisms of ageing and drugs' interference; the study of Parkinson’s disease and drugs' actions in Dementia; clinical studies on Molecular Medicine and Human Genetics on patients affected by neurological diseases (Dementia) or Alzheimer’s disease. Scientific research activity: 349 total papers: no. 129 on peer international reviews (IF about 350, only ISI publications); no. 66 Congress Proceedings and Acts; no. 154 communications in International Meetings, participating to no. 219 scientific Congress; officially invited to no. 214 Congress since 1993; from 2010 no. 56 as speaker; 9 Member of Organizing Committee or Session Chair/Co-Chair. International appointments as: (A) International ad hoc Reviewer for: - Research Founding Grants (Neuroscience) of The Wellcome Trust Foundation, London, United Kingdom (since 1994) - British Medical Council (asked 2014) inserted as - Reviewer’s Database for Founding of United Kingdom SBS, North Star House, Swinodon, U.K. - Listed as International Expert for the evaluation of Research Grant Programs of the European Commission Research Directorate General, Life Sciences: Health Research, European Union, Brussels. - Reviewer’s Database of Journal of Neuroscience - Reviewer’s Database of European Journal of Neurology And Committee Member of Italian Ministry for Scientific Research Grants (MIUR). (B) Member of the International Experts Panel of the Medical Science Monitor (since 2003), Albertson, New York, U.S.A. (C) Participant to ex Internship Program for U.S.A. students of New York Academy of Science, New York, U.S.A. Accredited Researcher for grants at National Institute of Health (NIH - U.S.A.). (D) Medical Credits at San Diego Alzheimer’s Disease Research Center Conference of University of California, San Diego, U.S.A. (E) Member of the Editorial Boards of: - Member of the Science Advisory Board – Arlington, U.S.A.. - Member of the Editorial Board of “Neurological Disorders & Therapy” – U.S.A. - VIP Member of EB of Neural Regeneration Research, Supervisor Ministry of Health - China (until 2013). - Member of EB of Journal of Neurological Disorders - Member of EB of “Aging and Neurodegeneration” – Anhui Medical University, China - Academic Editor of International Neuropsychiatric Disease Journal. - Member of EB of Journal of Depression and Anxiety – Los Angeles, California, U.S.A.. - Member of EB of International Journal of Emergency Mental Health and Human Resilience – Foster City, California, U.S.A.. - Member of EB of International Journal of Neurology Research – Sheung Wan, Hong Kong (China) - Member of EB of Journal of Neurology and Neuroscience – Wilmington City, Delaware, U.S.A.. (N) ad hoc Reviewer for over of 25 Journals: (in 1989) for Circulation Research; reviewer (from 1989) for Mechanisms of Ageing and Development; reviewer (in 2003) for Molecular Brain Research; reviewer (in 2004) of the Cochrane Dementia and Cognitive Improvement Group, Department of Clinical Gerontology, Oxford, U.K.; reviewer (since 2004) for Experimental Gerontology; reviewer (in 2004) for the “Bioastronautics Critical Path Roadmap Document”, Bioastronautics Research Division of NASA, U.S.A.; reviewer (since 2004) of The Journal of Clinical Pharmacology; reviewer (from 2011) of Complementary Medicine and Drug Discovery; reviewer (in 2011) for Drugs Today, Prous Thomson Reuters; reviewer (in 2011) for Neuropharmacology, Vascular Pharmacology, Journal of Neurological Disorder; reviewer (in 2012) for Vascular BMC Neurology; reviewer (in 2013) for Journal Neuroscience Research, Free Radical Research, Pharmacological Reports, PLOS ONE, Journal of Cytology & Histology, Neurological Research; reviewer (from 2014) for Neurochemical Research, Neural Regeneration Research, Journal Neurological Disorders (4 times), Molecular Neurobiology, Journal Proteome Research (3 times), Neuroscience Letters (3 times), Recent Patents on CNS Drug Discovery (Bentham Science Eds), Neuroscience Research, British Medical Journal, Metabolic Brain Disease.

Research Interests: Biochemical studies (Functional Proteomics and Metabolomics) on Physiopathology and Pharmacology of the Central Nervous System in experimental conditions of hypoxia, ischaemia, hyperammoniaemia, ipoglycaemia on the cerebral energy metabolism and actions of drugs on the brain energy state; molecular mechanisms of ageing and drugs' interference; the study of Parkinson’s disease and drugs' actions in Dementia; clinical studies on Molecular Medicine and Human Genetics on patients affected by neurological diseases (Dementia) or Alzheimer’s disease.

Dr. Ronald Swatzyna received his Masters of Science and Doctorate of Philosophy from The University of Texas Arlington. Currently, he is the Director of Electro-Neurophysiology Research, Director of Neurotherapy at the Tarnow Center for Self-ManagementSM, and is an associate of Brain Science International. Dr. Swatzyna is a licensed clinical social worker supervisor, board certified in neurotherapy and biofeedback by the Biofeedback Certification International Alliance (BCIA). For 18 years, Dr. Swatzyna has analyzed and treated the most diagnostically challenging cases in both inpatient and outpatient settings. As a researcher, he has presented and/or published over 50 peer-reviewed papers on brain dysfunction, psychotropic medication and other related topics at national and international conferences and is a Special Editor for WebmedCentral plus and Clinical EEG and Neuroscience. In 2011, Dr. Swatzyna was inducted into Sigma Xi: The Scientific Research Society: Rice University/Texas Medical Center Chapter and in 2013, he accepted an appointment to the board of directors. Dr. Swatzyna is a veteran of both Vietnam and the first Gulf War, and his personal battle with a traumatic brain injury and posttraumatic stress disorder has motivated him to become a leading expert in brain dysfunction.

Research Interest: involve the utility of EEG and qEEG technology to assist with medication selection and titration.

Professor of Neurology, Senior Neurologist, Chairman of the Neurosciences Department, Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, President of the Romanian Society of Neurology, President of the Society for the Study of Neuroprotection and Neuroplasticity (SSNN), member of the Academy of Medical Sciences, Romania, secretary of its Cluj Branch. He is also member of 13 scientific international societies (being member of the American Neurological Association (ANA) - Fellow of ANA (FANA) since 2012) and 7 national ones, being part of the executive board of most. Professor Dafin F. Muresanu is a specialist in Leadership and Management of Research and Health Care Systems (specialization in Management and Leadership, Arthur Anderson Institute, Illinois, USA, 1998 and several international courses and training stages in Neurology, research, management and leadership). Professor Dafin F. Muresanu is coordinator in international educational programs of European Master (i.e. European Master in Stroke Medicine, University of Krems), organizer and co-organizer of many educational projects: European and international schools and courses (International School of Neurology, European Stroke Organisation summer School, Danubian Neurological Society Teaching Courses, Seminars - Department of Neurosciences, European Teaching Courses on Neurorehabilitation) and scientific events: congresses, conferences, symposia (International Congresses of the Society for the Study of Neuroprotection and Neuroplasticity (SSNN), International Association of Neurorestoratology (IANR) & Global College for Neuroprotection and Neuroregeneration (GCNN) Conferences, Vascular Dementia Congresses (VaD), World Congresses on Controversies in Neurology (CONy), Danube Society Neurology Congresses, World Academy for Multidisciplinary Neurotraumatolgy (AMN) Congresses, Congresses of European Society for Clinical Neuropharmacology, European Congresses of Neurorehabilitation). His activity includes involvement in many national and international clinical studies and research projects, over 300 scientific participations as “invited speaker” in national and international scientific events, a significant portfolio of scientific articles (120 papers indexed on Web of Science-ISI, H-index: 14) as well as contributions in monographs and books published by prestigious international publishing houses. Prof. Dr. Dafin F. Muresanu has been honoured with: the Academy of Romanian Scientists, “Carol Davila Award for Medical Sciences / 2011”, for the contribution to the Neurosurgery book “Tratat de Neurochirurgie” (vol.2), Editura Medicala, Bucuresti, 2011; the Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca “Octavian Fodor Award” for the best scientific activity of the year 2010 and the 2009 Romanian Academy “Gheorghe Marinescu Award” for advanced contributions in Neuroprotection and Neuroplasticity.

Neuroprotection, Neuroplasticity, Neuroregeneration

Partner at a personal injury law firm specializing in T.B.I. The National Trial Lawyers “Top 100 Trial Lawyers”. BS Magna Cum Laude 1990 and Juris Doctorate 1993. Vice-Chairman of B.O.D. Mothers Against Drunk Driving National. & B.O.D. Brain Injury Alliance. 20x year keynote at National Brain Injury Conferences. All honorariums donated to charities. Authored Spring Break: A True Story of Hope and Determination regarding a brain injured college student who received long-term inpatient, outpatient care and rehabilitation. Awarded: US Senate Official Proclamation, US Congressional Citation, U.S. House of Representatives Special Congressional Recognition, 20+ awards for legal and charitable accomplishments.

Traumatic Brain Injury

Starting as a young entrepreneur from the age of 18, and having launched several start-up businesses in the security industry, Kevin carried on his career as a sales and marketing executive, which has included over 35 years with major corporate divisions of ADT, BOSCH and Honeywell International. Author, inventor and patent holder, Kevin has traveled to Europe, Asia, India, Australia, the Middle East, Africa, South and Central America, and throughout North America to see how the world really lives. Kevin also has a personal story and connection to Dementia. His first wife, Ginny, together for 32 years, died from Dementia, and thus he leads the fight against all forms with thoughts, words and deeds. In 2016, Jameson was awarded a Doctorate of Public Service, Honoris Causa. His establishment of the Dementia Society of America, is a mission in the making.

Dementia

Dr. Jera KRUJA is a Member of Scientific Committee at European Academy of Neurology and Professor of Neurology at Mother Theresa University Hospital Center. Since 2014 she is (European representative) at Teaching Course Committee, World Federation of Neurology. During 2013-2014 she is a Rector of University of Medicine, Tirana and Member of editing board of OA Publishing London, WebMed Central Brain Editor, Albanian Medical Journal, Bulletin of Medical Sciences, University of Medicine, Tirana. She worked at Health National Contact Point, European Commission, CORDIS Fp7 programme(2010-2013). From 2003, she is a reviewer of European Journal of Neurology, Clinical Epidemiology, Neuropsychiatric Disease and Treatment, Journal of Epidemiology and Community Health, Journal of Pediatric Epilepsy. She is a Trainer of European Academy of Epilepsy since February 2003. She is the President of Albanian Society of Neurology (ASN) during 1998-2007.

Neurology, Neuroradiology, Epidemiology

Starting as a young entrepreneur from the age of 18, and having launched several start-up businesses in the security industry, Kevin carried on his career as a sales and marketing executive, which has included over 35 years with major corporate divisions of ADT, BOSCH and Honeywell International. Author, inventor and patent holder, Kevin has traveled to Europe, Asia, India, Australia, the Middle East, Africa, South and Central America, and throughout North America to see how the world really lives. Kevin also has a personal story and connection to Dementia. His first wife, Ginny, together for 32 years, died from Dementia, and thus he leads the fight against all forms with thoughts, words and deeds. In 2016, Jameson was awarded a Doctorate of Public Service, Honoris Causa. His establishment of the Dementia Society of America, is a mission in the making.

Dementia

Starting as a young entrepreneur from the age of 18, and having launched several start-up businesses in the security industry, Kevin carried on his career as a sales and marketing executive, which has included over 35 years with major corporate divisions of ADT, BOSCH and Honeywell International. Author, inventor and patent holder, Kevin has traveled to Europe, Asia, India, Australia, the Middle East, Africa, South and Central America, and throughout North America to see how the world really lives. Kevin also has a personal story and connection to Dementia. His first wife, Ginny, together for 32 years, died from Dementia, and thus he leads the fight against all forms with thoughts, words and deeds. In 2016, Jameson was awarded a Doctorate of Public Service, Honoris Causa. His establishment of the Dementia Society of America, is a mission in the making.

Dementia

Dr. Jera KRUJA is a Member of Scientific Committee at European Academy of Neurology and Professor of Neurology at Mother Theresa University Hospital Center. Since 2014 she is (European representative) at Teaching Course Committee, World Federation of Neurology. During 2013-2014 she is a Rector of University of Medicine, Tirana and Member of editing board of OA Publishing London, WebMed Central Brain Editor, Albanian Medical Journal, Bulletin of Medical Sciences, University of Medicine, Tirana. She worked at Health National Contact Point, European Commission, CORDIS Fp7 programme(2010-2013). From 2003, she is a reviewer of European Journal of Neurology, Clinical Epidemiology, Neuropsychiatric Disease and Treatment, Journal of Epidemiology and Community Health, Journal of Pediatric Epilepsy. She is a Trainer of European Academy of Epilepsy since February 2003. She is the President of Albanian Society of Neurology (ASN) during 1998-2007.

Neurology, Neuroradiology, Epidemiology

Mootaz Salman is a pharmacist and researcher PhD student at the Biomolecular Sciences Research Centre (BMRC) at Sheffield Hallam University, working with Prof. Nicola Woodroofe and Dr. Matthew Conner’s research group and a member of the multi-institute Aquaporin research collaboration. His research interest focus on the identification of new drug targets for brain oedema and epilepsy through his work on the special water channels called “Aquaporins”. Mootaz graduated with Outstanding Distinction in his MSc winning the Sheffield Hallam University prize for the most scientific contribution and ranked 1st in year. His PhD research requires the skilled use of numerous techniques ranging from standard biochemical and molecular biology to cutting edge micro-array and laser confocal microscopy. Mootaz is an international ambassador at Sheffield Hallam University, ambassador for British Society of Experimental Biology (SEB); and STEM ambassador since 2014. He has given four invited oral presentations and talks at major international conferences in Canada, Netherlands, Romania and Japan along with three talks at a national level. He is also an active member in a number of scientific societies nationally and internationally including USA, Canada and Japan. He has been selected to be an abstract reviewer at two major international conferences; Brain 2015 in Canada and also for the upcoming Brain 2017 in Berlin, along with being an abstract reviewer and a member of poster judgement panel during the North of England Postgraduate Conference (NEPG) which is the UK's largest annual postgraduate conference for medical biosciences. Mootaz has successfully participated in organising a number of national and international high profile conferences and also he has been selected to chair scientific sessions at two national events.

Molecular Pharmacology, Neurochemistry, Astrocytes and Cerebral Aquaporins